Yes you can run in barefoot shoes, but if you are used to running in supportive maximalist shoes it may require a change in form and an adjustment period. If you would like to adopt a natural barefoot running style, start with lots of barefoot walking first! Pay close attention to your body and give yourself time to adapt. While it may take time and dedication to relearn this natural movement, running in barefoot shoes can be injury free and enjoyable.
Additional Barefoot Style Running Resources:
Irene Davis on Running Injuries & Minimalist Shoes
Running Rewired, by Jay Dicharry
Run For Your Life, by Mark Cucuzella
Older Yet Faster, by Keith Bateman and Heidi Jones